Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 22, Issue 4, Pages 447-453Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2010.04.003
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Funding
- National Institutes of Health [GM085089, GM078186, GM052549]
- Cystic Fibrosis Foundation
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The small GTPase Sari resides at the core of a regulatory cycle that controls protein export from the ER in COPII vesicles. Recent advances in minimally reconstituted systems indicate continual flux of Sari through GTPase cycles facilitates cargo concentration into forming vesicles that ultimately bud from membranes. During export from ER membranes, this GTPase cycle is harnessed through the combinatorial power of multiple coat subunits and cargo adaptors to sort an expanding array of proteins into ER-derived vesicles. The COPII budding machinery is further organized into higher-order structures at transitional zones on the ER surface where the large multidomain Sec16 protein appears to perform a central function.
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