Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 22, Issue 5, Pages 597-604Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2010.07.011
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Funding
- NIH/NIGMS
- March of Dimes
- Burroughs Wellcome Fund
- American Asthma Foundation
- Texas Advanced Research Program
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Planar cell polarity signaling governs a wide array of polarized cell behaviors in animals. Recent reports now show that PCP signaling is essential for the directional beating of motile cilia. Interestingly, PCP signaling acts in a variety of ciliated cell types that use motile cilia to generate directional fluid flow in very different ways. This review will synthesize these recent papers and place them in context with previous studies of PCP signaling in polarized cellular morphogenesis and collective cell movement.
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