Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 22, Issue 6, Pages 772-780Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2010.07.002
Keywords
-
Categories
Funding
- Duke Institute for Genome Sciences Policy
- March of Dimes Research Foundation [6-FY10-294]
Ask authors/readers for more resources
The centromere is a complex chromosomal locus where the kinetochore is formed and microtubules attach during cell division. Centromere identity involves both genomic and sequence-independent (epigenetic) mechanisms. Current models for how centromeres are formed and, conversely, turned off have emerged from studies of unusual or engineered chromosomes, such as neocentromeres, artificial chromosomes, and dicentric chromosomes. Recent studies have highlighted the importance of unique chromatin marked by the histone H3 variant CENP-A, classical chromatin (heterochromatin and euchromatin), and transcription during centromere activation and inactivation. These advances have deepened our view of what defines a centromere and how it behaves in various genomic and chromatin contexts.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available