Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 22, Issue 5, Pages 626-632Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2010.07.003
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- Deutsche Forschungsgemeinschaft DFG [LA121614-1]
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Formation of a patent vascular lumen is essential for the transport of oxygen, nutrients and waste products to and from tissues. No matter whether the blood vessel arises from vasculogenesis or angiogenesis, endothelial cells (EC) first have to form a cord, which subsequently lumenizes, in order to generate a functional vessel. During these processes, cellular junctions rearrange between adjacent ECs and are involved in EC polarization as a prerequisite for lumen formation. Here we review the role of EC junctions in vascular lumen formation within different vascular beds.
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