Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 21, Issue 1, Pages 59-67Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2008.12.002
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIGMS NIH HHS [R01 GM038499, R01 GM038499-17] Funding Source: Medline
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Molecular motors drive key biological processes such as cell division, intracellular organelle transport, and sperm propulsion and defects in motor function can give rise to various human diseases. Two dimeric microtubule-based motor proteins, kinesin-1 and cytoplasmic dynein can take over one hundred steps without detaching from the track. In this review, we discuss how these processive motors coordinate the activities of their two identical motor domains so that they can walk along microtubules.
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