Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 21, Issue 2, Pages 140-146Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2009.01.028
Keywords
-
Categories
Funding
- NCI NIH HHS [R01 CA082683, R01 CA082683-10] Funding Source: Medline
Ask authors/readers for more resources
In the 30 years since its discovery, tyrosine phosphorylation has emerged as a fundamentally important mechanism of signal transduction and regulation in all eukaryotic cells, governing many processes, including cell proliferation, cell cycle progression, metabolic homeostasis, transcriptional activation, neural transmission, differentiation and development, and aging. Perturbations in tyrosine phosphorylation underlie many human diseases, and in particular cancer, and this has prompted the development of inhibitors of tyrosine kinases implicated in disease, a number of which have been approved for clinical use. The following is a brief personal reflection on some of the salient findings over the past 30 years that led to the development of tyrosine kinase inhibitors for disease therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available