Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 21, Issue 6, Pages 785-795Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2009.09.007
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Funding
- Association for International Cancer Resarch (AICR)
- Telethon Foundation
- KINCON
- Italian Association for Cancer Research (AIRC)
- Fondo di Investimento per la Ricerca di Base (FIRB)
- Italian Ministry of Health
- Cariplo Foundation
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The spindle assembly checkpoint (SAC) is a feedback control system that monitors the state of kinetochore/microtubule attachment during mitosis and halts cell cycle progression until all chromosomes are properly aligned at the metaphase plate. The state of chromosome-microtubule attachment is implicated as a crucial factor in the checkpoint response. On the contrary, lack of tension in the centromere-kinetochore region of sister chromatids has been shown to regulate a pathway of correction of undesired chromosome-microtubule connections, while the presence of tension is believed to promote the stabilization of attachments. We discuss how tension-sensitive phenomena, such as attachment correction and stabilization, relate to the SAC and we speculate on the existence of a single pathway linking error correction and SAC activation.
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