Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 21, Issue 5, Pages 623-629Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2009.05.004
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Funding
- La Ligue Nationale Contre le Cancer
- ANR [ANR-08-BLAN-0078-01]
- Institut National du Cancer
- Agence Nationale de la Recherche (ANR) [ANR-08-BLAN-0078] Funding Source: Agence Nationale de la Recherche (ANR)
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Growing body of evidence confirms that cell-cell and cell-extracellular matrix adhesion within stem cell niches is essential for the establishment and maintenance of niche architecture, for the generation and transmission of short-distance regulatory signals, and for controlling the frequency and nature of stem cell divisions. Recent studies demonstrated that in many stem cell niches, adhesion to support cells and/or extracellular matrix determines orientation of stem cell division plane, thereby contributing to the control of stem cell self-renewal and differentiation. Thus, although further analysis of the implicated molecular mechanisms is required, cadherin-associated and integrin-associated events appear to play essential regulatory roles in tissue-specific stem cell niches.
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