Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 20, Issue 4, Pages 445-453Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2008.04.002
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Funding
- Cancer Research UK Funding Source: Medline
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Axonal transport of organelles has emerged as a key process in the regulation of neuronal differentiation and survival. Several components of this specialised transport machinery, their regulators and vesicular cargoes are mutated or altered in many neurodegenerative conditions. The molecular characterisation of these mechanisms has furthered our understanding of neuronal homeostasis, providing insights into the spatio-temporal control of membrane traffic and signalling in neurons with a precision not achievable in other cellular systems. Here, we summarise the recent advances in the field of axonal trafficking of different organelles, and the essential role of motor and adaptor proteins in this process.
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