Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 20, Issue 3, Pages 316-325Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2008.03.004
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Funding
- NCI NIH HHS [R01 CA118487-03, R01 CA118487] Funding Source: Medline
- NIGMS NIH HHS [R01 GM071004, R01 GM058012-04S1, R01 GM058012, R01 GM058012-09, R01 GM071004-04] Funding Source: Medline
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Since the first histone lysine demethylase KDM1 (LSD1) was discovered in 2004, a great number of histone demethylases have been recognized and shown to play important roles in gene expression, as well as cellular differentiation and animal development. The chemical mechanisms and substrate specificities have already been extensively discussed elsewhere. This review focuses primarily on regulatory mechanisms that modulate demethylase recruitment and activity.
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