Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 20, Issue 1, Pages 53-63Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2007.11.005
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Funding
- Cancer Research UK Funding Source: Medline
- NIGMS NIH HHS [R01 GM074215-03, R01 GM 074215, R01 GM074215] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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Kinetochores are proteinaceous complexes containing dozens of components; they are assembled at centromeric DNA regions and provide the major microtubule attachment site on chromosomes during cell division. Recent studies have defined the kinetochore components comprising the direct interface with spindle microtubules, primarily through structural and functional analysis of the Ndc80 and Dam1 complexes. These studies have facilitated our understanding of how kinetochores remain attached to the end of dynamic microtubules and how proper orientation of a kinetochore-microtubule attachment is promoted on the mitotic spindle. In this article, we review these recent studies and summarize their key findings.
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