Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 20, Issue 3, Pages 303-309Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2008.03.012
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Funding
- NIDDK NIH HHS [P01 DK059820-070006, P01 DK059820-010004, P01 DK059820-060006, R01 DK067320-01A1, R01 DK067320-04, R01 DK067320, R01 DK067320-03, R01 DK067320-02, P01 DK059820-020004, P01 DK059820] Funding Source: Medline
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Sirtuins (Sirts) compose a family of NAD(+)-dependent deacetylases and/or ADP-ribosyltransferases, which have been implicated in aging, metabolism, and tolerance to oxidative stress. Many of the biological processes regulated by Sirts result from the adaptation of complex gene-expression programs to the energetic state of the cell, sensed through NAD+ levels. To that respect, Sirts, and particularly the founding member of the family Sirt1, have emerged as important regulators of transcription, which they modulate both positively and negatively by targeting histories and transcriptional complex regulatory proteins, This review will focus on recent advances that have started deciphering how mammalian Sirts regulate transcriptional networks and thereby control physiology.
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