Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 20, Issue 6, Pages 707-715Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2008.09.008
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Funding
- DFG [SPP 1109, Hu 275/7-3, SPP 1111, Hu 275/8-3, SFB/TR 13, B1, SFB655, A2]
- DFG-funded Center for Regenerative Therapies Dresden
- Fonds der Chemischen Industrie
- Federal Ministry of Education and Research (BMBF)
- National Genome Research Network [NGFN-2, SMO RNAi, 01GR0402, PRI-S08T05]
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The switch of neural stem and progenitor cells from proliferation to differentiation during development is a crucial determinant of brain size. This switch is intimately linked to the architecture of the two principal classes of neural stem and progenitor cells, the apical (neuroepithelial, radial glial) and basal (intermediate) progenitors, which in turn is crucial for their symmetric versus asymmetric divisions. Focusing on the developing rodent neocortex, we discuss here recent advances in understanding the cell biology of apical and basal progenitors, place key regulatory molecules into subcellular context, and highlight their roles in the control of proliferation versus differentiation.
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