Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 20, Issue 5, Pages 583-588Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2008.05.002
Keywords
-
Categories
Funding
- NIH [KO8 CA098419]
- Culpeper Scholar Award
- AACR/Genentech BioOncology Career Award
- HHMI Early Career Award
Ask authors/readers for more resources
Integrin-mediated attachment of epithelial cells to extracellular matrix (ECM) is crucial for proper growth and survival. Although detachment leads to apoptosis, termed anoikis, recent work demonstrates that ECM detachment also robustly induces autophagy, a tightly regulated lysosomal self-digestion process that actually promotes survival. Autophagy presumably protects epithelial cells from the stresses of ECM detachment, allowing them to survive provided that they reattach in a timely manner. Currently, the intracellular signals linking integrin engagement to autophagy remain unclear, but certain growth factor, energy-sensing, and stress-response pathways represent attractive candidates. Moreover, autophagy may be a previously unrecognized mechanism utilized by detached cancer cells to survive anoikis, which may facilitate tumor cell dormancy, dissemination, and metastasis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available