Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 20, Issue 1, Pages 12-18Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2007.12.001
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While the original septin mutants were identified more than 30 years ago for their role in cytokinesis [Hartwell, LH: Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis. Exp Cell Res 1971, 69: 265-276], the architecture of septin complexes and higher order structures has remained a mystery up until very recently. Over the last few months a number of converging approaches have suddenly provided a wealth of structural information about the different levels of septin organization. Here, we review these advancements and highlight their functional consequences.
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