Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 20, Issue 6, Pages 609-615Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2008.09.006
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Funding
- NSF
- MDA
- NIH (NHLBI, NIBIB, NIDDK)
- NIH TG
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR022575] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL062352] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI087516] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R21AR056128] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB004489, R21EB003164, R01EB007049, R21EB004000] Funding Source: NIH RePORTER
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Cells may lack eyes to see and ears to hear, but cells do seem to have a sense of 'touch' that allows them to feel their microenvironment. This is achieved in part through contractility coupled adhesion to physically flexible 'soft' tissue. Here we summarize some of the known variations in elasticity of solid tissue and review some of the long-term effects of cells 'feeling' this elasticity, focusing on differentiation processes of both committed cell types and stem cells. We then highlight what is known of molecular remodeling in cells under stress on short time scales. Key roles for forces generated by ubiquitous and essential myosin-II motors in feedback remodeling are emphasized throughout.
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