Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 20, Issue 5, Pages 557-566Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2008.06.004
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Funding
- NIDCD NIH HHS [DC005965, R01 DC005965, R01 DC005965-06, R01 DC007704, DC007704, R01 DC007704-04] Funding Source: Medline
- NINDS NIH HHS [R01 NS046456-05, R01 NS046456] Funding Source: Medline
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Mechanotransduction, the conversion of a mechanical stimulus into an electrical signal is crucial for our ability to hear and to maintain balance. Recent findings indicate that two members of the cadherin superfamily are components of the mechanotransduction machinery in sensory hair cells of the vertebrate inner ear. These studies show that cadherin 23 (CDH23) and protocadherin 15 (PCDH15) form several of the extracellular filaments that connect the stereocilia and kinocilium of a hair cell into a bundle. One of these filaments is the tip link that has been proposed to gate the mechanotransduction channel in hair cells. The extracellular domains of CDH23 and PCDH15 differ in their structure from classical cadherins and their cytoplasmic domains bind to distinct effectors, suggesting that evolutionary pressures have shaped the two cadherins for their function in mechanotransduction.
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