Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 20, Issue 4, Pages 408-414Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2008.04.001
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Funding
- Biotechnology and Biological Sciences Research Council [BB/E019919/1] Funding Source: researchfish
- Medical Research Council [G0001128, G9722026] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/D011841, BB/512929/1, BB/E019919/1] Funding Source: Medline
- Cancer Research UK [C20675] Funding Source: Medline
- Medical Research Council [G0001128, G9722026] Funding Source: Medline
- Wellcome Trust [078304] Funding Source: Medline
- BBSRC [BB/E019919/1] Funding Source: UKRI
- MRC [G9722026, G0001128] Funding Source: UKRI
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Multivesicular endosomes/bodies (MVBs) sort endocytosed proteins to different destinations. Many lysosomally directed membrane proteins are sorted onto intralumenal vesicles, whilst recycling proteins remain on the perimeter membrane from where they are removed via tubular extensions. MVBs move to the cell centre during this maturation process and, when all recycling proteins have been removed, fuse with lysosomes. Recent advances have identified endosomal-sorting complex required for transport (ESCRT)-dependent and ESCRT-independent pathways in intralumenal vesicle formation and mechanisms for sorting recycling cargo into tubules. Cytoskeletal motors, through interactions with these machineries and by regulating MVB movement, help to coordinate events leading to a mature, fusion-competent MVB.
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