Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 20, Issue 1, Pages 4-11Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2007.12.002
Keywords
-
Categories
Funding
- Intramural NIH HHS [Z01 DK036118-14] Funding Source: Medline
Ask authors/readers for more resources
Multivesicular bodies (MVBs) are crucial intermediates in the trafficking of ubiquitinated receptors and other cargo destined for lysosomes. The formation of MVBs by invagination of the enclosomal limiting membrane is catalyzed by the enclosomal sorting complex required for transport (ESCRT) complexes, a process that has recently been visualized in three-dimensional detail by electron tomography. Structural and biochemical analysis of the upstream components, Vps27-Hse1, ESCRT-I, and ESCRT-II, shows how these complexes assemble and cluster cargo. Rapid progress has been made in understanding the assembly and disassembly of the ESCRT-III complex and the interactions of its subunits with MIT domain and other proteins. A key role for deubiquitination in the regulation of the system has been demonstrated. One central question remains largely unanswered, which is how the ESCRTs actually promote the invagination of the endosomal membrane.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available