Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 20, Issue 4, Pages 386-392Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2008.03.016
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Funding
- NIGMS NIH HHS [R01 GM073994-03, R01 GM073994] Funding Source: Medline
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The nuclear envelope is a double-layered membrane that encloses the nuclear genome and transcriptional machinery. In dividing cells of metazoa, the nucleus completely disassembles during mitosis, creating the need to re-establish the nuclear compartment at the end of each cell division. Given the crucial role of the nuclear envelope in gene regulation and cellular organization, it is not surprising that its biogenesis and organization have become active research areas. We will review recent insights into nuclear membrane dynamics during the cell cycle.
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