Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 20, Issue 5, Pages 541-550Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2008.05.004
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Funding
- Cell Migration Consortium (NIH) [U54 GM64346]
- KMH [P50 GM68762]
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Understanding the structural adaptation and signaling of adhesion sites in response to mechanical stimuli requires in situ characterization of the dynamic activation of a large number of adhesion components. Here, we review high-resolution live cell imaging approaches to measure forces, assembly, and interaction of adhesion components, and the activation of adhesion-mediated signals. We conclude by outlining computational multiplexing as a framework for the integration of these data into comprehensive models of adhesion signaling pathways.
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