4.5 Article

Regulation of membrane trafficking in polarized epithelial cells

Journal

CURRENT OPINION IN CELL BIOLOGY
Volume 20, Issue 2, Pages 208-213

Publisher

CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2008.01.003

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Funding

  1. NIGMS NIH HHS [GM070736, R01 GM070736-03, R01 GM070736] Funding Source: Medline

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Polarized epithelial cells continuously sort transmembrane proteins to either apical or basolateral plasma membrane domains. Research in recent years has made tremendous progress in understanding the molecular mechanisms of the major pathways to either basolateral or apical domain. This understanding will help us elucidating how these pathways are interconnected in ensuring maintenance of cell polarity and integrity of epithelial monolayers.

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