Journal
CURRENT OPINION IN CARDIOLOGY
Volume 25, Issue 3, Pages 238-242Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HCO.0b013e328338574d
Keywords
cholesterol; genetics; genome-wide association; lipids; triglycerides
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Funding
- Sarnoff Cardiovascular Research Foundation
- NIH [RC2 HL101864, RC1 HL099793, RC1 HL099634]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [RC1HL099793, RC1HL099634, RC2HL101864] Funding Source: NIH RePORTER
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Purpose of review In this review, we will highlight recent advances in identifying genes and gene regions responsible for the variation in serum lipid levels. We will also consider the next directions for research based on these advances. Recent findings Large-scale genome-wide association studies have successfully screened common variants across the genome for association with serum lipids and have generated novel hypotheses about the causes of serum lipid variation. Summary Deep sequencing of genome-wide association signals promises to expand the catalogue of variants responsible for serum lipid variation and, with a full catalogue of variants, we may develop a panel of polymorphisms with clinical utility. In parallel, functional exploration of the genome-wide association signals should expand our knowledge of lipoprotein metabolism and generate targets for pharmacologic intervention.
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