Journal
CURRENT OPINION IN CARDIOLOGY
Volume 25, Issue 3, Pages 229-237Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HCO.0b013e3283383e2c
Keywords
association; blood pressure; genetics
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Funding
- NIH [K23-HL080025, R01-HL098283]
- Doris Duke Charitable Foundation
- Burroughs Wellcome Fund Career Award for Medical Scientists
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL098283, K23HL080025] Funding Source: NIH RePORTER
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Purpose of review Hypertension is a complex trait with multiple environmental and genetic contributors. Until recently, linkage studies of rare Mendelian disorders of hypertension and hypotension have produced the most notable progress toward understanding the heritable basis of blood pressure (BP). Association studies to identify common variants have been limited in the past by small sample sizes and most findings have lacked replication. Recent findings Recently, well powered, targeted candidate gene and genome-wide association studies have reported reproducible associations between rare and common genetic variants and BP and hypertension at the population level. Summary Identification of novel genes will lead to an improved understanding of BP regulation and the potential for novel therapies.
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