Journal
CURRENT OPINION IN CARDIOLOGY
Volume 24, Issue 4, Pages 351-357Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HCO.0b013e32832ac21a
Keywords
coronary heart disease; lipoprotein a; peripheral arterial disease; statins; stroke
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Funding
- Hellenic Atherosclerosis Society
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Purpose of review To provide an update of the literature describing the link between lipoprotein a and vascular disease. Recent findings There is evidence that elevated plasma lipoprotein a levels are associated with coronary heart disease, stroke and other manifestations of atherosclerosis, Several mechanisms may be implicated, including proinflammatory actions and impaired fibrinolysis. Summary Lipoprotein a potentially represents a useful tool for risk stratification in the primary and secondary prevention setting. However, there are still unresolved methodological issues regarding the measurement of lipoprotein a levels. Targeting lipoprotein a in order to reduce vascular risk is hampered by the lack of well tolerated and effective pharmacological interventions. Moreover, it has not yet been established whether such a reduction will result in fewer vascular events. The risk attributed to lipoprotein a may be reduced by aggressively tackling other vascular risk factors, such as low-density lipoprotein cholesterol.
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