Journal
CURRENT OPINION IN CARDIOLOGY
Volume 24, Issue 4, Pages 333-339Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HCO.0b013e32832c58ba
Keywords
antihypertensive pharmacogenetics; genes; hypertension; personalized medicine
Categories
Funding
- National Heart, Lung, and Blood Institute of the United States National Institutes of Health [HL63082]
Ask authors/readers for more resources
Purpose of review To describe recent advances in anti hypertensive pharmacogenetics and discuss challenges related to translating this knowledge into 'personalized medicine' for the initial drug treatment of hypertension. Recent findings Recent studies included both prospective and retrospective analyses ranging from small clinical investigations of 42 participants to large, multicenter, randomized, outcome-based clinical trials of nearly 40000 individuals. Treatment with drugs from five classes of antihypertensives was evaluated in these studies. The duration of treatment ranged from week-long follow up for blood pressure response to a decade-long follow up for clinical outcomes. In total, associations with 12 different candidate genes were assessed. These studies present the now familiar mixture of significant and nonsignificant pharmacogenetic findings that are sometimes consistent with, sometimes inconsistent with, previous findings in antihypertensive pharmacogenetics. Summary Recent research in anti hypertensive pharmacogenetics has added to the existing evidence base, and novel genes and variants as well as new methodologies are cause for continued optimism. However, translation of genomic science to clinical settings has not kept pace with growing interest in personalized medicine for hypertension. New research paradigms may be needed to translate pharmacogenetics into clinical tools. Clinical application will also require a trained clinical workforce, validated genetic tests, and payers willing to fund pretreatment testing.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available