Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 30, Issue -, Pages 40-44Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.copbio.2014.05.001
Keywords
-
Funding
- National Science Foundation
Ask authors/readers for more resources
Chinese hamster ovary (CHO) cells are important hosts for the production of therapeutic proteins. Recent genome sequencing studies provide an initial baseline of information useful for understanding cell line performance in terms of product quality attributes. However, the lack of a well-established reference genome together with concerns about genome stability have not yet permitted the community to define the detailed relationship between the genome and cell line performance. Emerging efforts to define a new reference genome, together with new data on genome stability, herald an era where cell line's with defined genomes can be combined with defined process parameters to yield product quality attribute control.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available