Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 25, Issue -, Pages 69-77Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2013.08.013
Keywords
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Funding
- Ministry of Science and Technology of China [2011CB809106]
- National Natural Science Foundation of China [21222501]
- Whitaker International Biomedical Engineering Fellowship
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Single-molecule approaches in biology have been critical in studies ranging from the examination of physical properties of biological macromolecules to the extraction of genetic information from DNA. The variation intrinsic to many biological processes necessitates measurements with single-molecule resolution in order to accurately recapitulate population distributions. Microfluidic technology has proven to be useful in the facilitation and even enhancement of single-molecule studies because of the precise liquid handling, small volume manipulation, and high throughput capabilities of microfluidic devices. In this review we survey the microfluidic toolbox available to the single-molecule specialist and summarize some recent biological applications of single-molecule detection on chip.
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