4.7 Review

Technological applications arising from the interactions of DNA bases with metal ions

Journal

CURRENT OPINION IN BIOTECHNOLOGY
Volume 28, Issue -, Pages 17-24

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2013.10.013

Keywords

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Funding

  1. Basic Science and Public Welfare & Safety Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [2009-0080602, 2012M3A2A1051683]
  2. Industrial Source Technology Development Program of the Ministry of Knowledge Economy (MKE) [2010-10038683]

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An intense interest has grown in the unique interactions of nucleic acids with metal ions, which lead to the formation of metal-base pairs and the generation of fluorescent nanomaterials. In this review, different types of metal-base pairs, especially those formed from naturally occurring nucleosides, are described with emphasis also being given to recent advances made in employing these complexes to govern enzymatic reactions. The review also contains a comprehensive description of DNA-templated inorganic nanomaterials such as silver nanoclusters which possess excellent fluorescence properties. Finally, a summary is given about how these materials have led to recent advances in the field of nanobiotechnology.

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