Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 26, Issue -, Pages 85-90Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2013.10.006
Keywords
-
Funding
- National Science Foundation [084653, 0821381, 1264502]
- National Institutes of Health [1R21AI1095788]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0846453, 1264526] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0821381, 1264502] Funding Source: National Science Foundation
Ask authors/readers for more resources
The intestinal microbiota plays an important role in a wide range of functions and whole body homeostasis. Recent advances have linked microbiota dysbiosis to conditions ranging from Crohn's disease to cancer. The restoration or strengthening of the intestinal microbiota through diet-based approaches such as probiotics and prebiotics has been proposed for combating the onset or progression of these diseases. In this review, we highlight the importance of postbiotics for the manipulation of the intestinal microbiota, with special emphasis on systems biology computational tools and targeted metabolomics for the rational discovery and identification of these bioactive molecules. The identification of novel postbiotics and the pathways responsible for their production should lead to improved mechanistic understanding of the role that specific probiotics, prebiotics, and postbiotics have in restoring intestinal microbiota composition and function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available