Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 24, Issue 1, Pages 95-104Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2012.10.021
Keywords
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Funding
- National Institute on Drug Abuse [P30 DA018310]
- Department of Energy [DE-SC0006642]
- U.S. Department of Energy (DOE) [DE-SC0006642] Funding Source: U.S. Department of Energy (DOE)
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The metabolome refers to the entire set of small molecules, or metabolites, within a biological sample. These molecules are involved in many fundamental intracellular functions and reflect the cell's physiological condition. The ability to detect and identify metabolites and determine and monitor their amounts at the single cell level enables an exciting range of studies of biological variation and functional heterogeneity between cells, even within a presumably homogenous cell population. Significant progress has been made in the development and application of bioanalytical tools for single cell metabolomics based on mass spectrometry, microfluidics, and capillary separations. Remarkable improvements in the sensitivity, specificity, and throughput of these approaches enable investigation of multiple metabolites simultaneously in a range of individual cell samples.
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