Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 24, Issue 6, Pages 1000-1009Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2013.03.001
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Funding
- National Institutes of Health, National Science Foundation, Defense Advanced Research Projects Agency
- Bill and Melinda Gates Foundation
- National Science Foundation Graduate Research Fellowship
- Stanford Graduate Research Fellowship
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1066100] Funding Source: National Science Foundation
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Biotechnological production of high value chemical products increasingly involves engineering in vivo multi-enzyme pathways and host metabolism. Recent approaches to these engineering objectives have made use of molecular tools to advance de novo pathway identification, tunable enzyme expression, and rapid pathway construction. Molecular tools also enable optimization of single enzymes and entire genomes through diversity generation and screening, whole cell analytics, and synthetic metabolic control networks. In this review, we focus on advanced molecular tools and their applications to engineered pathways in host organisms, highlighting the degree to which each tool is generalizable.
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