Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 24, Issue 2, Pages 239-246Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2012.11.006
Keywords
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Funding
- Agricultural and Food Research Initiative Competitive [2008-35318-04541]
- National Science Foundation [MCB-0919987]
- European Research Council (ERC) project SAMIT (FP7 program)
- Minna James Heineman Stiftung
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0919987] Funding Source: National Science Foundation
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The complex metabolic networks in plants are highly compartmentalized and biochemical steps of a single pathway can take place in multiple subcellular locations. Our knowledge regarding reactions and precursor compounds in the various cellular compartments has increased in recent years due to innovations in tracking the spatial distribution of proteins and metabolites. Nevertheless, to date only few studies have integrated subcellular localization criteria in metabolic engineering attempts. Here, we highlight the crucial factors for subcellular-localization-based strategies in plant metabolic engineering including substrate availability, enzyme targeting, the role of transporters, and multigene transfer approaches. The availability of compartmentalized metabolic network models for plants in the near future will greatly advance the integration of localization constraints in metabolic engineering experiments and aid in predicting their outcomes.
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