Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 24, Issue 6, Pages 1037-1043Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2013.03.007
Keywords
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Funding
- ESF-project Nanocell
- EU-project Eurobiosyn
- European Union Seventh Framework Programme [298326]
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In vitro biocatalytic systems have moved far beyond established uses in food, diagnostic, and chemical applications. As new strategies to construct and manage multiple enzymes in ever more complex systems are developed, novel applications emerge. In the field of chemistry, complex protein networks are applied to enable the production of fine chemicals, such as dihydroxyacetone phosphate, and even bulk chemicals, such as biofuels, from cheap sugars. Cellfree protein synthesis is applied to expanding protein and nucleic Acid biochemistry and enabling novel assay formats, while programmable DNA-circuits can be exploited to engineer sensitive detection methods. Novel developments in chemical analytics such as real-time mass spectrometry to follow the metabolism online, directed physical assembly of network members facilitating substrate channeling, and encapsulation forming biofunctional subunits enable a better control and potential for optimization.
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