Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 24, Issue 4, Pages 606-611Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2013.01.003
Keywords
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Funding
- NSF [DMR 1063771]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1015486] Funding Source: National Science Foundation
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Scaffold proteins are involved in many enzyme cascades in signaling pathways and metabolic processes. The study of scaffolds occurring in biological systems advances at a rapid pace and recently developed engineered synthetic scaffolds enable the precise placement of components of an enzymatic cascade within nanometer distances. Recent experimental results demonstrate significantly increased throughput of enzymatic cascades as a result of the utilization of a scaffold, but our understanding of the mechanisms responsible for this increase is not complete. We discuss the physics of diffusive transport processes relevant for these unique reaction-diffusion systems.
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