Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 24, Issue 5, Pages 909-915Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2013.03.021
Keywords
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Funding
- NIH [RO1 DK 042876, R01DK 071614]
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The gastrointestinal (GI) tract is a complex system characterized by multiple cell types with a determined architectural arrangement. Tissue engineering of the GI tract aims to reinstate the architecture and function of all structural layers. The key point for successful tissue regeneration includes the use of cells/biomaterials that elucidate minimal immune response after implantation. Different biomaterial choices and cell sources have been proposed to engineer the GI tract. This review summarizes the recent advances in bioengineering the GI tract with emphasis on cell sources and scaffolding biomaterials.
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