Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 23, Issue 3, Pages 431-436Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2011.11.017
Keywords
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Funding
- National Institutes of Health
- Bill and Melinda Gates Foundation
- Crohns and Colitis Foundation of America
- Colorado Center for Biofuels and Biorefining
- Howard Hughes Medical Institute
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Until recently, the study of microbial diversity has mainly been limited to descriptive approaches, rather than predictive model-based analyses. The development of advanced analytical tools and decreasing cost of high-throughput multi-omics technologies has made the later approach more feasible. However, consensus is lacking as to which spatial and temporal scales best facilitate understanding of the role of microbial diversity in determining both public and environmental health. Here, we review the potential for combining these new technologies with both traditional and nascent spatio-temporal analysis methods. The fusion of proper spatio-temporal sampling, combined with modern multi-omics and computational tools, will provide insight into the tracking, development and manipulation of microbial communities.
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