Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 23, Issue 5, Pages 644-650Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2012.01.013
Keywords
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Funding
- German Research Foundation [SPP1230-Ca311/2, SFB738-C9]
- Federal Ministry of Education and Research [InTherGD-01GU0834, ReGene-01GN1003B]
- European Commission [PERSIST-222878, HeMiBio-266777]
- Mukoviszidose Institut gGmbH [S03/11]
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Custom-made designer nucleases have evolved into an indispensable platform to precisely alter complex genomes for basic research, biotechnology, synthetic biology, or human gene therapy. In this review we describe how transcription activator-like effector nucleases (TALENs) have rapidly developed into a chief technology for targeted genome editing in different model organisms as well as human stem cells. We summarize the technological background and provide an overview of the current state-of-the-art of TALENs with regard to activity and specificity of these nucleases for targeted genome engineering.
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