Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 23, Issue 5, Pages 727-735Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2011.12.029
Keywords
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Funding
- Advanced Research Projects Agency - Energy (ARPA-E), U.S. Department of Energy [DE-AR0000091]
- National Science Foundation [EEC-0540879]
- Joint BioEnergy Institute
- U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research [DE-AC02-05CH11231]
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Heterologous production of polyketide compounds, an important class of natural products with complex chemical structures, was first demonstrated with Streptomyces parvulus in 1984. Although Streptomyces strains are good first options for heterologous polyketide biosynthesis, their slow growth kinetics prompt other hosts to also be considered. Escherichia coli provides key elements of an ideal host in terms of the growth rate, culture conditions, and available recombinant DNA tools. Here we review the current status and potential for metabolic engineering of polyketides in E. coli.
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