Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 23, Issue 5, Pages 672-678Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2012.02.002
Keywords
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Funding
- National Institutes of Health [R00GM081450]
- National Academies Keck Futures Initiative [NAFKI-SB5]
- National Science Foundation [MCB-0943393]
- Office of Naval Research [N00014-11-1-0363]
- DARPA YFA Program [N66001-11-1-4137]
- ARMY Research Office [W911NF-11-1-044]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [943383] Funding Source: National Science Foundation
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Just as synthetic organic chemistry once revolutionized the ability of chemists to build molecules (including those that did not exist in nature) following a basic set of design rules, cell-free synthetic biology is beginning to provide an improved toolbox and faster process for not only harnessing but also expanding the chemistry of life. At the interface between chemistry and biology, research in cell-free synthetic systems is proceeding in two different directions: using synthetic biology for synthetic chemistry and using synthetic chemistry to reprogram or mimic biology. In the coming years, the impact of advances inspired by these approaches will make possible the synthesis of nonbiological polymers having new backbone compositions, new chemical properties, new structures, and new functions.
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