Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 23, Issue 5, Pages 703-711Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2012.01.003
Keywords
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Funding
- Swiss National Science Foundation [CR32I3_125426]
- European Research Council under the European Community's Seventh Framework Programme (FP7/ERC) [259043-CompBioMat]
- Excellence Initiative of the German Federal and State Governments [EXC 294]
- Swiss National Science Foundation (SNF) [CR32I3_125426] Funding Source: Swiss National Science Foundation (SNF)
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The field of synthetic biology is rapidly expanding and has over the past years evolved from the development of simple gene networks to complex treatment-oriented circuits. The reprogramming of cell fate with open-loop or closed-loop synthetic control circuits along with biologically implemented logical functions have fostered applications spanning over a wide range of disciplines, including artificial insemination, personalized medicine and the treatment of cancer and metabolic disorders. In this review we describe several applications of interactive gene networks, a synthetic biology-based approach for future gene therapy, as well as the utilization of synthetic gene circuits as blueprints for the design of stimuli-responsive biohybrid materials. The recent progress in synthetic biology, including the rewiring of biosensing devices with the body's endogenous network as well as novel therapeutic approaches originating from interdisciplinary work, generates numerous opportunities for future biomedical applications.
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