Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 23, Issue 1, Pages 34-40Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2011.11.006
Keywords
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Funding
- National Institutes of Health and General Medicine [P50-GM085764, RO1-GM69811, RO1-GM089976]
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A mechanistic understanding of gene regulatory network dynamics requires quantitative single-cell data of multiple network components in response to well-defined perturbations. Recent advances in the development of fluorescent biomarkers for proteins, detection of RNA and interactions, microfluidic technology, and high-resolution imaging have set the stage for a host of new studies that elucidate the important roles of stochasticity and cell-cell variability in response to external perturbations. In this review, we briefly describe methods for high-resolution visualization and the control of gene expression, along with application of these novel methods to recent studies involving gene networks.
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