Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 22, Issue 4, Pages 492-501Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2011.05.507
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A growing number of polymer therapeutics have entered routine clinical use as nano-sized medicines. Early products were developed as anticancer agents, but treatments for a range of diseases and different routes of administration have followed - recently the PEGylated-anti-TNF Fab Cimzia (R) for rheumatoid arthritis and the PEG-aptamer Macugen (R) for age related macular degeneration. New polymer therapeutic concepts continue to emerge with a growing number of conjugates entering clinical development, for example PEGylated-aptamers and a polymer-based siRNA delivery system. 'Hot' topics of the past 2 years include; emerging issues relating to polymer safety, the increasing use of biodegradable polymers, design of technologies for combination therapy, potential biomarkers for patient individualisation of treatment and Regulatory challenges for 'follow-on/generic' polymer therapeutics.
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