Journal
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
Volume 27, Issue 2, Pages E92-E96Publisher
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.neuropsych.13100240
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- Indian Council of Medical Research (ICMR), India
- ICMR
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Early cell death is a feature of neurodegenerative disorders. Telomere shortening is related to premature cellular senescence and could be a marker for cellular pathology in neurological diseases. Relative telomere length in dementia (N=70), Huntington's disease (N=35), ataxia telangiectasia (N=9), and age-group matched control samples (N=105) was measured as relative telomere copy/single copy gene ratios. Individuals with Huntington's disease had the lowest relative telomere copy/single copy gene ratio (0.21), followed by ataxia telangiectasia (0.31) and dementia (0.48). The younger control group had the highest relative telomere copy/single copy gene ratio (1.07). The reduced telomere length could be indicative of shared biological pathways across these disorders contributing to cellular senescence.
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