Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 22, Issue 5, Pages 706-714Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2011.04.004
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Funding
- NSERC [RGPIN 326982-10, STPGP 381002-09]
- NSERC-CIHR [CHRPJ 385981-10]
- HSFO [T6946]
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Cardiac tissue engineering offers the promise of creating functional tissue replacements for use in the failing heart or for in vitro drug screening. The last decade has seen a great deal of progress in this field with new advances in interdisciplinary areas such as developmental biology, genetic engineering, biomaterials, polymer science, bioreactor engineering, and stem cell biology. We review here a selection of the most recent advances in cardiac tissue engineering, including the classical cell-scaffold approaches, advanced bioreactor designs, cell sheet engineering, whole organ decellularization, stem cell-based approaches, and topographical control of tissue organization and function. We also discuss current challenges in the field, such as maturation of stem cell-derived cardiac patches and vascularization.
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