Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 21, Issue 5, Pages 670-676Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.copbio.2010.05.011
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Funding
- National Institutes of Health [EB006532, P20 RR024237]
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR024237] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB006532] Funding Source: NIH RePORTER
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Life is a dynamic process driven by the complex interplay between physical constraints and selection pressures, ranging from nutrient limitation to inhibitory substances to predators. These stressors are not mutually exclusive; microbes have faced concurrent challenges for eons. Genome-enabled systems biology approaches are adapting economic and ecological concepts like tradeoff curves and strategic resource allocation theory to analyze metabolic adaptations to simultaneous stressors. These methodologies can accurately describe and predict metabolic adaptations to concurrent stresses by considering the tradeoff between investment of limiting resources into enzymatic machinery and the resulting cellular function. The approaches represent promising links between computational biology and well-established economic and ecological methodologies for analyzing the interplay between physical constraints and microbial fitness.
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