Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 21, Issue 1, Pages 12-20Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2010.01.007
Keywords
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Funding
- ICA
- Leibnitz Graduate School Systems Biology Lab-on-a-Clop (S-BLOC)
- European Union (EFRE)
- Ministry of Innovation, Science, Research, and Technology of North-Rhine
- European Research Council [203428]
- European Research Council (ERC) [203428] Funding Source: European Research Council (ERC)
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Single cells represent the minimal functional unit of life. A major goal of biology is to understand the mechanisms operating in this minimal unit. Nowadays, analysis of the single cell can be performed at unprecedented resolution using new lab-on-achip devices and advanced analytical methods. While cell handling and cultivation devices can be classified into finite volume reactors and flow systems, the analytical approaches differ in respect to invasive (i.e. chemical) and noninvasive (i.e. biological/living cell) analysis. Using these new and exciting technologies cell-to-cell differences, originating from regulatory circuits and distinct microenvironments, can now be explored. For example, it could be shown that the rates of transcription and translation are stochastic Chemical and biological single cell analyses provide an unprecedented access to the understanding of cell-to-cell differences and basic biological concepts
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