Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 21, Issue 5, Pages 704-709Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.copbio.2010.06.005
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Funding
- JDRF
- NIH
- AHA
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB004496] Funding Source: NIH RePORTER
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Host integration and performance of engineered tissues have been severely limited by the lack of robust strategies to generate patent vascularization and tissue perfusion. This review highlights a selection of exciting developments in vascularization approaches for tissue engineering research. Current strategies for vascularization in tissue engineering are related to growth factor signaling and delivery, cell transplantation, bioactive smart matrix materials, and directed fabrication. Application of these techniques to in vivo models has resulted in a number of robust host vascular responses, especially with synergistic and engineered bioactive systems. The future outlook of the field includes refinement and development of new technologies for vascularization and combining these techniques with functional repair models for metabolically active tissues and relevant disease states.
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