Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 20, Issue 4, Pages 486-491Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2009.08.005
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Funding
- Ruth M Kirschstein National Research Service [F32 GM78975]
- NIH [R01 GM074712-01A1, R01 CA118486]
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Constructing novel biological systems that function in a robust and predictable manner requires better methods for discovering new functional molecules and for optimizing their assembly in novel biological contexts. By enabling functional diversification and optimization in the absence of detailed mechanistic understanding, directed evolution is a powerful complement to 'rational' engineering approaches. Aided by clever selection schemes, directed evolution has generated new parts for genetic circuits, cell-cell communication systems, and non-natural metabolic pathways in bacteria.
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