Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 19, Issue 6, Pages 590-596Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.copbio.2008.10.012
Keywords
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Funding
- NIH [1R21HL091197, 1R01GM085128]
- NSF [CBET-0545860]
- David and Lucile Fellowhsip in Science and Engineering
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R21HL091197] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM085128] Funding Source: NIH RePORTER
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Many biologically active natural products are produced by the host organisms using dedicated biosynthetic pathways. The programming rules of these pathways may be rationally manipulated through combinatorial biosynthesis to produce natural products that contain structural variations or enhanced pharmacological properties. Furthermore, these pathways contain enzymes that can be harvested as powerful biocatalysts for the synthesis of both new drugs and existing blockbuster therapeutics. This review will highlight recent advances in exploring natural product biosynthetic pathways for new compounds, novel enzymes and useful biocatalysts.
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